DID YOU KNOW WHICH TYPES OF WATER USED FOR PHARMACEUTICAL PRACTISE–
IF YOU DON’T KNOW THEN let’s FIND OUT WITH US.
As per Indian pharmacopoeia, there are three types of water to be used in pharmaceutical practice.
Water for injection
Sterile water for injection
so lets study these waters in deep
In purified water, water is totally free from volatile and non-volatile impurities
We can also define as the water which is free from volatile and non volatile impurities is called purified water.
2)this purified water is colourless, odourless,tasteless,clear liquid,
3)the process to make purified water are distillation method or ion exchange treatment reverse osmosis or any other suitable process.
4)purified water is easily used to get contaminated by micro organism hence this water should not be used the parenteral preparation.
5)storage-it should be stored in tightly closed container.
6)PH in between 4.5 to 7.0
7)test to be comply for chloride ,sulphate,nitrate,ammonia,nitrites and heavy metal
In IP is describe that whenever distilled water is prescribe purified water is to be dispensed.
WATER FOR INJECTION
Water for injection(WFI) is nothing but the water is free from volatile, non-volatile impurities, micro organism and pyrogens.
Water which is free from volatile and non-volatile , micro organism and pyrogens is called water for injection.
Prepared by distillation of potable water, purified water or distlled water.
Water for injection contains no additional substances
It must be free from pyrogens and comply the test for pyrogen
Storage-it should be stored in tightly closed container
As visual water for injection can be contaminated with micro organism during it preparation.
The bacterial contaminants are mostly gram negative bacteria
In water for injection bacterial growth can be prevented by heating and storing at 80 degree/celcius
It is used in the preparation of parenteral dosage form having PH 5.0 to 7.0
Water for injection must be used within 24 hrs for the preparation of parenteral products
The common and most include substance are pyrogens,
They are derived from the cell walls of bacteria which injection causes rise in temperature than the normal.
Pyrogens means, pyro-means heat
Gen-means to generate
Pyrogen consist of lipo polysachharides of which liquid portion appears to be the active pyrogen.
STERILE WATER FOR INJECTION
As per Indian pharmacopoeia sterile water for injection is clear,colourless,odourless or tasteless liquid which is sterilized and neatly packed.
It is free from dust, dirt, dissolved and undissolved impurities, micro organism and pyrogens
The PH for sterile water injection in between 4.5 to 7.5
The test must be comply are sterility and pyrogen.
The total solids should not be more than 0.004% w/v for sterile water for injection in glass container of the 30 ml and not more than 0.003% w/v for 30 ml-100ml sized
Sterile water for injection contains no bacterial statics agent
This water should be store in single dose container not larger than 1litre of sized.
this is all
TYPES OF WATER USED FOR PHARMACEUTICAL PRACTISE-